Welcome to CBB

The Center for Biocatalysis and Bioprocessing (CBB) is a microbial biomanufacturing and research facility that bridges the gap between laboratory discovery and commercial-scale bioprocessing solutions. Located at the University of Iowa, CBB offers microbial fermentation, recombinant protein expression, and downstream protein purification services for a wide variety of clients, including international corporations and early-stage start-up companies. For clients interested in clinical applications, a cGMP suite is available to manufacture of proteins under the quality standards defined by the U.S. Food and Drug Administration specifically for Phase 1 clinical trials.  

 

By combining the technical capabilities of a university-based pilot-scale CDMO with the expertise of affiliated faculty and researchers, the CBB serves as a trusted partner to biotech startups, vendors for the life science community, pharmaceutical companies, and academic innovators. Our facility supports innovation across multiple sectors, supporting the development and scale-up of protein-based therapeutics, specialty enzymes, reagent proteins, and other next-generation biologics. In addition, CBB plays a key role in bioprocessing workforce development through graduate training and NIH-funded biomanufacturing fellowships, thereby helping to shape the future of the biotech and life sciences industries.  

We Work with a Wide Range of Clients across the Biotech, Life Sciences, and Pharmaceutical Spaces

We welcome clients from diverse industry sectors, including biotech startups seeking scalable biomanufacturing, academic research laboratories advancing translational science, life science vendors supporting basic and applied research worldwide, as well as large multinational pharmaceutical manufacturers and government agencies involved in drug development and public health initiatives. Our services are accessible to clients regardless of geographic location, ensuring professional support for protein production, purification, and bioprocess development. 

How to Start a Service with CBB?

We’re here to support your project every step of the way. Getting started with the Center for Biocatalysis and Bioprocessing (CBB) is simple. Clients can request services by completing our Client Request Form online. After submitting the form, a CBB representative will contact you within 2-3 business days to confirm your request and to schedule an initial consultation.  

 

During this initial consultation, your project requirements will be discussed in a non-confidential manner. CBB will then evaluate whether our facility can meet your specific needs. If so, a Confidential Disclosure Agreement (CDA) template will be provided for your consideration. In parallel, we will share a ballpark estimate of the costs for your project.  
 
Upon execution of the CDA, a more in-depth discussion will be used to provide a more accurate assessment of the costs for CBB’s bioprocessing services. Services can begin once a Master Service Agreement is in place and a Project Ordered is created specifically tailored toward your bioprocessing needs.  
 
Our team will be with you through every step to ensure a smooth and compliant bioprocessing experience.  

Bioprocessing Services

Fermentation, protein purification, & cGMP production for Phase-1 clinical trials

Academic Opportunities

Predoctoral Iowa Biotech Fellowship, CBB & NIH fellowships available

Annual Conference

The CBB hosts an annual conference focusing on innovations in the biocatalytic sciences.

"I worked for CBB since they first started with fermentation in their present location! I had previous experiences running 2000 liter fermenters at Solvay Animal Health. I really enjoyed watching the fermenters being delivered and set up. I worked closely with B. Braun company getting them up and running. The team came together over the next couple years. They have all become very experienced operators in the upstream and downstream processing! Everyone works well together and produces high quality product! I have since retired and miss my coworkers."

CBB Operator Working in the Lab

30 +

Years of Manufacturing Experience
CBB Operator Working in the Lab

265 +

Fellowships Awarded to Students
CBB Operator Working in the Lab

55 +

Associated UI Faculty

News

Maria Spies, Ph.D.

Saturday, November 15, 2025

Tyler J. Woodward

Wednesday, October 15, 2025

Hossein Zare

Wednesday, October 15, 2025

Reza Nejadnik

Wednesday, October 15, 2025

Meet Some of Our Associated Faculty

Office of VP for Research Events

Book Matters: James Costa and Elizabeth Yale promotional image

Book Matters: James Costa and Elizabeth Yale

Thursday, April 9, 2026 7:00pm to 8:30pm
Prairie Lights Books
Join us for a reading and discussion to celebrate The Descent of Man: An Annotated Edition of Darwin’s Classic Work, annotated by James Costa, professor of biology and executive director of the Highlands Biological Station at Western Carolina University, and Elizabeth Yale, associate professor of history at the University of Iowa.
Navigating ARPA-H: Overview and Lessons Learned promotional image

Navigating ARPA-H: Overview and Lessons Learned

Friday, April 10, 2026 1:00pm to 2:00pm
Virtual

The Research Development Office is hosting a virtual information and panel session on Friday, April 10, from 2 to 3 p.m. Join us virtually to learn more about ARPA-H. During the session, the RDO will give an overview of the programs, and two successful awardees will discuss their experiences, share their insights, and respond to your questions.

Panelists

Karen Dunn Lopez (Professor, Nursing)

Jill Kolesar (Dean, College of Pharmacy; Jean M. Schmidt Chair and Professor, Drug Discovery)

Registration

Reg...

College of Medicine Events

Targeting the Psychological Roots, Not Branches, of Vaccine Confidence promotional image

Targeting the Psychological Roots, Not Branches, of Vaccine Confidence

Friday, April 10, 2026 3:00pm to 3:45pm
Biology Building East
Aaron Scherer examines the psychological roots of vaccine confidence and how to communicate more effectively about science.
Aaron Scherer: Targeting the Psychological Roots, Not Branches, of Vaccine Confidence promotional image

Aaron Scherer: Targeting the Psychological Roots, Not Branches, of Vaccine Confidence

Friday, April 10, 2026 3:00pm to 3:45pm
Biology Building East
This is one of a series of talks organized by Iowa City Darwin Day on April 10 and 11

College of Pharmacy Events

GradFest 2026 promotional image

GradFest 2026

Wednesday, April 15, 2026 9:00am to 6:00pm
Iowa Memorial Union (IMU)

Are you planning to graduate this spring? Attend GradFest 2026 in the IMU Main Lounge to pick up your cap and gown, customize your Class of 2026 keepsake, and snag exclusives and discounts as you complete your graduation checklist.

You’ll also be able to gain “Life After College” tips and advice, explore commencement accessories, order graduation announcements and class rings, and browse other on-site offerings. Plus, enjoy free snacks and fun activities throughout the event.

Check back on this...

Graduate and Professional Students: Let's Do Lunch! promotional image

Graduate and Professional Students: Let's Do Lunch!

Friday, April 17, 2026 11:00am to 1:00pm
Sciences Library
Graduate & Professional Students: Let's Do Lunch!